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The current study was framed with a view to develop a simple, sensitive and a rapid RP-TLC/Densitometry method for quantification of Triclosan (TCS) in various cosmetic preparations available in local market. Moreover, robustness testing was planned to be performed employing Central Composite Design (CCD). The desired chromatographic separation was achieved on RP-TLC/Densitometry plates precoated with Silica gel 60 GF 254 on Aluminum sheet, employing methanol : glacial acetic acid as mobile phase in the ratio of 7 : 3 v/v and detection was carried out at 281 nm. The mobile phase used gave an excellent symmetrical peak for TCS. The method was found linear over a wide range of 2 - 200 ng/band. The optimized method was validated by measuring various validation parameters. CCD was employed to check the robustness of the method at three-factor levels. The developed and optimized method was used to quantify TCS in 20 different cosmetic preparations procured from local market. The proposed and developed RP-TLC/Densitometry method can be applied for routine analysis of TCS in cosmetic preparations and can also be extended to the analysis in pharmaceuticals and food products. Key words: Central Composite Design, Cosmetic preparations, Triclosan, RP-TLC/Densitometry, Validation.

Central Composite Design to develop a robust RP-TLC/Densitometry method for quantification of Triclosan in cosmetic preparations