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The yields of consecutive reactions in a micro-fluid device were predicted by using Monte Carlo simulation. It was found that the yield of main product was improved by using a micro-fluid device when the ratio of the reaction rate constants is k1/k2 >1. The yield prediction map was also made by using non-dimensional Damkohler Number Da and the ratio of the reaction-rate constants k1/k2. The validation experiments of four kinds of consecutive reactions were conducted. Next, the micro-fluid system of 20 parallel-connected micro-fluid devices was developed. The maximum flow rate of the micro-fluid system was 10 mm/s, which corresponds to 315 t/year. Evaluation of the chemical performance of the micro-fluid system was conducted using a nitration reaction. It was found that the micro-fluid system increased the production scale without decreasing the yield of the products.

Yield Prediction Method of a Reaction in a Micro-Fluid Device and Experimental Proof of Increased Production Using Parallel-Connected Devices