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The thyroid hormone 3, 5, 3’-triiodothyronine (T3) is a key regulator of the development, differentiation, and physiology of all cells in an organism. One of the most studied effects of the thyroid hormone is its control of the basal metabolic rate. Thus, modifications in thyroid hormone levels can produce several alterations, including modifications to the REDOX environment, alterations to signal transduction on several levels, and finally cell death. The aim of this review is to describe primary, secondary, and tertiary hypothyroidism from embryonic and fetal development through to the adult organism. In addition, we explore thyroid hormone resistance causes hypothyroidism. Furthermore, we describe how genetic

Hypothyroidism: diagnosis and screening, genetic influences, and treatment options