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Succinic acid as a bio-based green and versatile catalyst has been employed for one-pot facile three-component Biginelli synthesis of 3,4dihydropyrimidin-2-(1H)-ones/thiones derivatives under solvent-free conditions with high to excellent yields and short reaction times. This sustainable procedure has notable benefits such as easy-to-handle, green, low-cost and non-toxic catalyst, materials available, simple work-up with no necessity of chromatographic purification steps, one-pot and solvent-free conditions. The products have been characterized by melting points and 1H NMR spectroscopy.

chiang mai university journal

Succinic Acid As a Green and Bio-Based Catalyst assisted solvent-free one-pot Biginelli synthesis of biologically active 3,4-dihydropyrimidin-2-(1H)-ones/thiones derivatives