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It is reported that insulin-like growth factor binding protein-1 (IGFBP-1) is one of the IGFBPs and modulates the IGF action (1). Since IGFBP-1 is reported to be regulated by insulin, it is speculated that meals and nutritional condition influence IGFBP-1 secretion from the liver (2). We measured the 24 hour secretion of serum IGFBP-1 to study the diurnal variation and the relation with calorie intake. We also measured IGFBP-1 levels in fasting normal children to study the age dependent reference value.

clinical pediatric endocrinology

Diurnal Variation of Serum Insulin-like Growth Factor Binding Protein-1 in Three Boys and Fasting Insulin-like Growth Factor Binding Protein-1 Levels in Normal Children