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GH and pyridinoline are known to be involved in bone metabolism in children. Recently, PTH-related protein (PTHrP) was identified and using RIA (1) for PTHrP we have investigated the pathophysiological role of PTHrP in normal and diseased states (2,3). PTHrP, which is the main factor causing humoral hypercalcemia of malignancy (HHM), is suggested to have also some role in bone metabolism in normal children, but the detail has not been clarified. Therefore in this study, we investigated urinary excretion and correlation of GH, pyridinoline, PTHrP and calcium/phosphate in normal children.

Correlation between Urinary Growth Hormone, Pyridinoline, Parathyroid Hormone-Related Protein and Calcium/Phosphate Excretion in Normal Children