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This retrospective study aimed to clarify the characteristics of bone maturation using longitudinal data in short-stature prepubertal children. Children with chronological ages (CAs) of 4.5-10.5 yr with nonfamilial idiopathic short stature (ISS, n = 95), familial ISS (FSS, n = 21), and short-stature children born small for gestational age (SGA, n = 23) were selected, of which 435 left-hand plain radiographic images were evaluated. Bone age (BA) delay was defined as BA minus CA. In the ISS group, there was a statistically significant difference in median BA delay among the CA groups (P &lt; 0.001), as median BA delay gradually increased from 5- to 9-yr-old groups (-1.06 [range, -2.17 to 0.27] and -2.45 [range, -4.35 to -0.32] yr, respectively). In the FSS group, median BA delays were approximately -1 yr in all CA groups. In the SGA group, median BA delay gradually decreased from 7- to 10-yr-old groups (-1.96 [range, -2.99 to 0.56] and -0.04 [range, -2.44 to 0.92] yr, respectively), but with no significant difference (P = 0.647). The heavier weight of children with FSS and the probable earlier onset of adrenarche in children born SGA compared to those with ISS could have affected bone maturation.

clinical pediatric endocrinology

Bone age in prepubertal children with nonfamilial or familial idiopathic short stature and prepubertal short-stature children born small for gestational age: a longitudinal data analysis