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It has been suggested that insulin-like growth factors (IGFs) may play a role in fetal growth. In serum, IGFs bind to specific binding proteins (IGFBPs) that might modulate bioavailability of IGFs. In the present study, we measured IGFBPs in fetal cord serum and examined the relationship between IGFBPs and birth weight. Fetal cord serum was obtained at delivery (37-41 gestational weeks) from 31 babies born to normal mothers, the birth weights ranged from 1,980 to 4,415 g. Serum IGFBP-2 and -3 were analyzed by Western immunoblot (WIB) and Western ligand blot (WLB), and the IGFBP value was expressed as a percentage of the reference serum value. IGFBP-3 was also measured by Radioimmunoassay (RIA). The serum levels of total form and free form IGF-I and -II were measured. In cord serum, IGFBP-2 values were increased and IGFBP-3 values decreased compared with normal adult sera. The IGFBP-2 values in cord sera by WIB and WLB inversely correlated with birth weight, serum levels of free IGF-I and -II, and total IGF-I levels. The birth weight positively correlated with serum IGF-I levels (total and free) and serum levels of free IGF-II. The IGFBP-3 by RIA, WEB and WLB did not correlate with birth weight. One interpretention of these data might be that changes of IGFBP-2 values modulate free IGFs that play a role in growth.

Birth Weight, Insulin-like Growth Factors (IGFs) and Their Binding Proteins in Newborn Babies