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Twelve adult patients with growth hormone deficiency (GHD) were studied in regard to serum levels of immunoglobulins, immunoglobulin G (IgG) subclasses, natural killer (NK) activities, interferon (IFN) augmented NK activities and lymphokine activated killer (LAK) activities before and after one month of human growth hormone (hGH) treatment. They were compared with 114 age-matched controls. All the patients were diagnosed as having GHD in childhood and had been treated with hGH for more than 5 years. The present study was performed 1 to 7 years after the cessation of hGH treatment.Serum immunoglobulin G1 (IgG1) levels and IFN augmented NK activities in the patients were significantly lower than in the controls, although NK and LAK activities of the patients were normal. Therefore it was concluded that NK and LAK activities were maintained at normal levels without hGH in adults who had been treated with hGH, although IFN augmented NK activities were reduced without it. It seems that longer treatment with hGH is needed to produce normal levels of serum IgG1 and IFN augmented NK activities.

Immunological Abnormalities in Adults Treated with hGH in Childhood; Responses to One Month Trial of hGH