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Recent researches suggested that personal individual's genetic background is contributed to the susceptibility to obesity. The present of this study is to investigate whether single nucleotide polymorphisms (SNPs) of glutathione s-transferase mu 1 ( GSTM1 ) gene are susceptibility to obesity in Korean population. In present study, two SNPs (rs1056806 [Asp142Asp], rs3815029 [promoter]) of GSTM1 gene were genotyped in 117 overweight/obese subjects with a body mass index (BMI)≥23 kg/m 2 and 125 nonoverweight/obese with a BMI of 18.5-23.0 kg/m 2 . Genotyping of two SNPs (rs1056806 and rs3815029) was determined by sequencing after polymerase chain reaction. Logistic regression models (codominant, dominant, recessive, and log-additive models) and allele analysis were used to calculate odds ratio, 95% confidence interval, and P -values. Significant association was considered at P &lt;0.05. Tested two SNPs in GSTM1 genes did not show any significant association with obesity (rs1056806, P =0.24 in codominant 1 model; rs3815029, P =0.59 in codominant 1, P =0.09 in codominant 2, P =0.16 in dominant, P =0.09 in recessive, and P =0.07 in log-additive models). In summary, these results indicate that SNPs of GSTM1 gene did not associated with susceptibility of obesity in the Korean population.

Lack of association between glutathione s-transferase mu 1 (GSTM1) gene polymorphisms and obesity