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Sleep deprivation (SD) inhibits normal biorhythms, causing physical and mental problems. To solve the problems caused by SD, fundamental measures are needed. I investigated change of recovery by rest time in psychological aspect after repetitive SD. The mice were divided into four groups: control 24-hr rest after 24-hr SD group, 48-hr rest after 24-hr SD group, and 72-hr rest after 24-hr SD group (n=20 in each group). I carried out SD in the water cage included multiple platforms. Repetitive SD executes for 36 days. I measured weight every week after SD for 6 weeks. To check emotional condition, I carried out intruder-evoked aggression test and modified forced swimming test. In the present results, group treated 24-hr rest and 48-hr rest after 24-hr SD showed lower natural aggressiveness and high depression. However, group treated 72-hr rest after 24-hr SD indicated emotional changes to recover the normal conditions. In the weight change, all group showed significant decrease compared to control for 6 weeks. I suggest that appropriate rest time after SD can help to restore emotional change.

Study on emotion by rest time in mice with repetitive sleep deprivation