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Objective: Urinary tract infection in children may be associated with renal damage. In literature, there are reports that present the existence of lesions at high rates in renal scintigraphy, which is performed four to six months after the febrile urinary tract infection. However, the recent data about the changes in these lesions over time is very limited. In this study, we aimed to analyse the changes in renal damage over time in young children with urinary tract infection and the factors related with the progression of renal damage. Material and Methods: In this study, we retrospectively evaluated 143 patients, who were 1–24 months of age and detected to have renal damage via technetium-99m dimercaptosuccinic acid scintigraphy, which was performed at least 90 days after the first febrile urinary tract infection diagnosis, and who had follow-up scintigraphy after 2 years. Results: Among the 143 children, who were found to have renal damage on DMSA scintigraphy, 78 (54.5%) patients remained unchanged while 27 (18.8%) showed progression and 38 (26.5%) showed regression in findings. There were no differences between groups in terms of gender or age. In the group with progression in renal damage, 21/27 (77.8%) children had grades IV–V vesicoureteral reflux and 22 (81.5%) had recurrent urinary tract infection. Multivariate 2 Kargın Çakıcı E ve ark.

Evaluation of the Changes in Renal Damage Over Time in Children Aged 1–24 Months with Urinary Tract Infection