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In 107 dogs with canine lymphoma, induction chemotherapy was performed with L-asparaginase (10,000 IU/m) and prednisolone (median dose, 40 mg/m), and the initial responses were analyzed. The initial remission rate was high, at 92.3%(CR:27.9% and PR:64.4%), in 104 assessed cases. In terms of anatomical sites, the remission rate for multicentric lymphoma was significantly higher than that for cutaneous lymphoma (p=0.045). No significant differences were observed in remission rates by stage, substage, or prior corticosteroid administration. No severe side effects, such as anaphylaxis or clinically evident pancreatitis, were seen. The results suggested that L-asparaginase induction chemotherapy was an effective early induction agent for downstaging canine lymphoma. Key word:Canine, L-asparaginase, Lymphoma, Remission rate, Side effects 1)Veterinary Teaching Hospital, Azabu University, 1-17-71 Fuchinobe, Chuo, Sagamihara, Kanagawa 252-5201, Japan 2)School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo, Sagamihara, Kanagawa 252-5201, Japan 3)Yamada Animal Hospital, 2-1, Kourikitanomachi, Neyagawa, Osaka 572-0080, Japan Corresponding author:Takuya Maruo Telephone:042-754-7111 Facsimili:042-769-2418 Email address:maruo@azabu-u.ac.jp Received:November 18, 2009 / Accepted:October 19, 2010 Original Article

Initial response to L-asparaginase and prednisolone induction chemotherapy in 107 cases of canine lymphoma