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Coronavirus disease-19 (COVID-19) caused by the severeacute respiratory syndrome coronavirus 2 is anongoingviral epidemic that originated in China in December 2019 To date, no specific treatment is available for COVID-19 However, several studies havereported the benefits ofvitaminsA, C, and D and zinc in critically illpatients and in those with various infections, including respiratory infections and sepsis The objective of this review is to discuss the potential role of vitamin A, C, and D and zinc supplementation in enhancing immune response, and reducing the severity of symptoms, and mortality rate in patients with COVID-19 Several clinical studies haveshown that different doses of vitamins A, C, and D and/or zinc supplements reduce the ventilator, length of intensive care unit stay, and mortality rate Future randomized clinical trials are warranted to conclusively establish protocols forthe optimal doses of vitamin A, C, and D, as well as zinc supplements for improved clinical outcomes in patients with COVID-19 © 2020 The Author(s)

current research in nutrition and food science

The Potential Influence of Vitamin A, C, and D and Zinc Supplements on the Severity of COVID-19 Symptoms and Clinical Outcomes: An Updated Review of Literature