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The present study was undertaken to evaluate the hypocholesterolemic activity of buttermilk, milk fat globule membrane (MFGM) and Enterococcus faecium FFNL-12 in rat model. Thirty-sixth male Abino rats were divided into six groups. The first one (coded as G1) was fed a standard diet containing 10% corn oil as fat source while remaining five (coded G2 to G6) were fed hypercholesterolemic diets in which oil was replaced with animal grease. Animals subjected to treatment G1 served as healthy control while those in G2 were assigned as hypocholesterolemic animals which did not receive any treatment. The remaining experimental groups were designed to assess the hypocholesterolemic effect of intragastric adminstartion of dose of 109 CFU/Kg body weight of Enterococcus faecium FFNL-12 (G3), Enterococcus faecium FFNL-12/butter milk (G4), buttermilk (G5) and milk fat globule membrane (MFGM). After four weeks, animals were evaluated in relation to growth, fecal pH, organs weight, serum lipid profile, antioxidant activity of liver tissue, liver and heart function and liver histopathological architecture. Results revealed that animals fed hypercholesterolemic diet (G2-G6) had significantly lower faecal pH and liver weight compared with those fed standard diet (G1). Treatments applied to animals fed hypercholesterolemic diet with the above mentioned additions (G3 to G6) appeared to improve both cardiac and hepatic functions, serum lipid profile and glucose concentration and liver histopathological architecture compared with animals subjected to G2 treatment. In most cases, treatment with MFGM appeared to be the most effective to avoid adverse effects associated to feeding hypercholesterolemic diet. MFGM fraction as well as E. faecium FFNL-12/buttermilk combination were effective in reducing serum lipids and glucose levels to the normal range. This combination also had potential antioxidant activity and ability to improve liver and heart functions.

In vivo anti-hypercholesterolemic effect of buttermilk, milk fat globule membrane and Enterococcus faecium FFNL-12