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Blood levels of vitamin A and E were examined in cows after administration of a new type water-soluble granule premix of vitamin AD3E comparing with the conventional powder type. In animals given the watersoluble granule type either mixed in feed or injected by oral route , tocopherol levels markedly increased showing the same patterns, peaking in serum and red blood cells at 24 hrs . Serum retinylpalmitate levels also increased markedly showing a peak at 4 hrs. In cows given the powder type of the same vitamin content , increases of blood tocopherol and serum retinylpalmitate were slower and slight . A single dosing of the watersoluble granule type at 250,000 IU/100 kg or more of vitamin A and 1,000 mg/100 kg or more of vitamin E, was effective resulting in significant increase of the blood levels .

Levels of Vitamin A and E in Blood of Cows after Administration of Water-Soluble Granules of Vitamin AD3E Premix