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An attenuated Aujeszky's disease virus(ADV) vaccine with deletions in thymidine kinase and glycoproteing III genes was evaluated for an experimental dual infection with ADV and Actinobacillus pleuropneumoniae in specificpathogen-free pigs. Pigs were assigned to vaccinated and unvaccinated control groups. Four of the 8 pigs(4 weeks old) were vaccinated with the attenuated ADV vaccine, and the remaining pigs were not vaccinated. All pigs were inoculated intranasally with ADV(106.0TCID50/ head) and serotype 1 of A. pleuropneumoniae (106.2 CFU/ head) at 7 and 8 weeks respectively. The duration and severity of clinical signs of vaccinated pigs after challenge with ADV and A. pleuropneumoniae were obviously reduced, compared with those not vaccinated. Two out of 4 unvaccinated control pigs died during the experiment, but none of the vaccinated pigs did. These results indicate the efficacy of the vaccine on the dual infection with ADV and A. pleuropneumoniae.

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Efficacy of a g III-/ TK-Modified Live Aujeszky's Disease Virus Vaccine for Experimental Dual Infection with AD Virus and Actinobacillus pleuropneumoniae in Pigs