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An attenuated Aujeszky's disease virus (ADV) vaccine with deletions in thymidine kinase and glycoprotein-gIII genes was evaluated. Sixteen 3-day-old piglets, which had been vaccinated with 1,10-1 or 10-2 dose of the vaccine, were challenge-exposed intranasally to a virulent strain of ADV on postvaccination day (PVD) 11 together with 5 non-vaccinated piglets of the same age. None of the vaccinates exhibited adverse reactions to the vaccination, and all were protected against the challenge-exposure, while 3 of the 5 control piglets developed severe clinical signs and died after challenge-exposure. Four pigs vaccinated with one dose of the vaccine at 4weeks of age were challenged intranasally with the virulent strain on PVD 21 together with 4 non-vaccinated pigs. After exposure, the vaccinates developed no clinical signs except for Slight fever and shed ADV for 4 to 6days. On the other hand, in all of the control pigs, clinical signs for 3 to 5days, fever for 6days, and virus shedding for 8 to 13days were observed. Anti-ADV antibodies were detected in the vaccinates on PVD 7, and the titers increased rapidly after challenge-exposure. Twelve piglets, 3-day-old, were vaccinated with one dose of the vaccine, and 3 each of which were exposed intranasally to the virulent strain on PVD 4, 7, 10, or 14. Non-vaccinated piglets were exposed concurrently. None of the vaccinates exhibited adverse reactions to the vaccination. Two of the 3 vaccinates exposed on PVD 4 died, and the remaining one survived. All of the vaccinates exposed on PVD 7, 10, or 14 were protected, while all of the control piglets developed severe clinical signs and died after challenge-exposure. These results indicate the safety and efficacy of the vaccine.

Safety and Efficacy of an Attenuated Aujeszky's Disease Virus Vaccine with Deletions in Thymidine Kinase and Glycoprotein-gIII Genes