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In order to clarify changes in blood levels after administration of selenium and tocopherol, oral administration of premix A and B and intramuscular injection of E・SE were carried out in the horse. Oral administration of 50 g/day of premix A and 25 g/day of premix B for 8 weeks, resulted in marked increases of two weeks later, while serum tocopherol level and blood glutathioneperoxidase (GSH-Px) activity did not increase. However, in a horse administered premix B only, blood GSH-Px activity increased slightly eight weeks later. When injected with 2 to 2.5 ml/100 kg of E・SE one of four times at 2 or 4 weeks interval, serum selenium levels increased rapidly one day later and a high concentration was maintained over two to four weeks. In particular, serum selenium remained at high levels above 100 ppm after two injections. Serum

Changes in Blood Levels of Selenium and Tocopherol after Administration in the Horse