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Thirty-six Japanese Black cows infected with Fasciola sp. were divided into three groups. Group A of 12 was treated with 6mg/kg of tricrabendazole (T), Group B of 13 with 12 mg/kg of T and Group C of 11 with no drug. T was administered as a drench at once. Egg per gram (EPG) became negative in 83.3% of group A and 92.3% of group B. Plasma glutamate dehydrogenase (GLDH) decreased significantly in activity after treatment. No noticeable changes were observed in EPG and plasma GLDH in group C. One cow of group B showed mild anorexia on the next day of treatment, but recovered from it naturally after one day. Tricrabendazole was proved to be a practical anthelmintic against Fasciola sp.

Therapeutic Effect of Tricrabendazole on Spontaneous Bovine Fascioliasis