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The response of the urinary bladder epithelium in NCI-Black-Reiter (NBR) rats to administration of N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN), a potent carcinogen in rodents, was examined. Male NBR rats were exposed to 0.05% BBN in the drinking water for 8 weeks, or no added chemical. Microscopically, simple hyperplasia was observed in the urinary bladder epithelium of treated rats sacrificed at the end of week 4. Moreover, after 8 weeks administration of BBN, papillary or nodular (PN) hyperplasia and squamous metaplasia were produced. Levels of DNA synthesis, as indicated by incorporation of 5-bromo-2'-deoxyuridine, areas of simple and PN hyperplasia in rats treated by BBN were significantly increased than in non-treated ones at the end of week 8. These results indicate that the urinary bladder of NBR male rats is very responsive to BBN insult.

journal of toxicologic pathology

Significant induction of epithelial cell proliferation in the urinary bladders of NCI-black-reiter male rats by N-butyl-N-(4-hydroxybutyl) nitrosamine.