English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Glycerol has been reported to have a promoting effect in pulmonary tumorigenesis induced by 4-nitroquinoline-1-oxide (4NQO) in ddY mice, but not in mice pretreated with urethane (UR) or 3-methylcholanthrene (3MC). To investigate the modifying effects of glycerol on the development of lung tumors induced by UR or 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), transgenic CB6F1 mice carrying the human proto-type c-Ha-ras gene (rasH2 mice) and their wild littermates (non-Tg mice) were given a single intraperitoneal injection of UR or NNK. One week after the treatment of the carcinogen, they were allowed to drink 5% solution of glycerol ad libitum for 26 weeks. In rasH2 mice, alveolar/bronchiolar hyperplasias, adenomas, and carcinomas were induced in UR alone, UR + glycerol, NNK alone, and NNK + glycerol groups, but there were no significant differences in the incidences and multiplicity between UR alone and UR + glycerol groups or NNK alone and NNK + glycerol groups. In non-Tg mice, hyperplasias and adenomas were induced in UR alone, UR + glycerol, NNK alone, and NNK + glycerol groups, but no significant difference was observed between UR alone and UR + glycerol groups or NNK alone and NNK + glycerol groups. These results suggest that glycerol does not have a promoting effect in pulmonary carcinogenesis in rasH2 mice induced by urethane or NNK.

journal of toxicologic pathology

Lack of Modifying Effect of Glycerol in Pulmonary Carcinogenesis in rasH2 Mice Induced by Urethane or 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).