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The objective of this presentation is to summarize the major pathogenic mechanisms responsible for perturbations of endocrine function that result in important diseases in domestic and laboratory animals. For each major category, several specific disease problems have been selected to illustrate the functional and morphologic lesions that are characteristic for either a naturally occurring endocrinopathy or endocrine disturbances induced by the administration of xenobiotic chemicals. Disorders of the endocrine system are encountered in a wide variety of animal species and, as in human patients, often present challenging diagnostic problems. The examples to be discussed, by necessity, will be highly selective and include disease problems investigated by our laboratory as well as data from the literature.

Pathogenic Mechanisms of Endocrine Disease in Domestic and Laboratory Animals.