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We investigated the relationship between CD8+ T cell anti-feline immunodeficiency virus (FIV) activity and FIV proviral DNA load integrated in mononuclear cells. The anti-FIV activity and the proviral DNA load were correlated, and the number of proviral DNA copies was high in cats with decreased anti-FIV activity. Particularly, no anti-FIV activity was detected in the cats staged as having an acquired immunodeficiency syndrome (AIDS)-related complex or AIDS, and the number of proviral DNA copies was obviously increased compared to those in the cats in the asymptomatic stage. These results suggest that decreased anti-FIV activity destroys the control of in vivo FIV replication, which leads to an increased proviral DNA load with the progression of the clinical stage of disease.

journal of veterinary medical science

Ability of CD8<sup>+</sup> T Cell Anti-Feline Immunodeficiency Virus (FIV) Activity and FIV Proviral DNA Load in Mononuclear Cells in FIV-Infected Cats

Ability of CD8+ T Cell Anti-Feline Immunodeficiency Virus (FIV) Activity and FIV Proviral DNA Load in Mononuclear Cells in FIV-Infected Cats

Ability of CD8⁺ T Cell Anti-Feline Immunodeficiency Virus (FIV) Activity and FIV Proviral DNA Load in Mononuclear Cells in FIV-Infected Cats