English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Matricellular proteins, a non-structural extracellular matrix (ECM) component, bind to and modulate various molecules including growth factor, cytokine, protease, other ECM components and cell membrane receptors. While most matricellular proteins are hardly expressed in normal adult tissue, they are re-expressed in heart tissue during cardiac diseases. The present study aimed to clarify the mRNA expression profile of matricellular proteins [secreted protein acidic and rich in cysteine: SPARC, hevin, thrombospondin (TSP)-1, -2 and -4, CCN1 and 5, tenascin (Tn) C and N, periostin and osteopontin (OPN)] in hypertrophied right ventricle (RV) of monocrotaline (MCT)-induced pulmonary hypertensive rats. Male Wistar rats were intraperitoneally treated with MCT or saline. Two or three weeks after MCT treatment, echocardiography was performed, and mRNA expression of matricellular proteins was measured by real-time polymerase chain reaction. MCT (2 weeks) induced pulmonary hypertension, RV dysfunction and hypertrophy, which were all worsened 3 weeks after MCT treatment. Expression of mRNA for SPARC, hevin, TnC, TSP-1, -2 and -4, CCN1 and 5, periostin and OPN but not TnN was significantly upregulated in RV of MCT (2 weeks)-treated rats. Expression of mRNA for TSP-4, CCN1 and 5 and periostin was continuously increased in RV of MCT (3 weeks)-treated rats. The present study for the first time revealed the mRNA expression profile for matricellular proteins in RV of MCT-treated rats for 2 or 3 weeks, which will be helpful to clarify the relationship for matricellular proteins and pathogenesis of MCT-induced RV hypertrophy.

Expression profile of matricellular proteins in hypertrophied right ventricle of monocrotaline-induced pulmonary hypertensive rats