English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

During pregnancy, the mammary epithelium and its supporting vasculature undergo extensive growth and proliferation in preparation for lactation, which is thought to be dependent on vascular endothelial growth factor (VEGF). We investigated the expression of VEGF, using immunohistochemistry and immunoblotting, in the mouse mammary gland during the reproductive cycle. Immunohistochemical studies localized VEGF protein predominantly in the cytoplasm of the mammary epithelium and revealed it to be strongly expressed in late pregnancy and early lactation. In addition, immunoblot analysis revealed a 45-kD VEGF band, corresponding to the homodimer of the VEGF-A₁₆₄ isoform, with increased expression towards the end of pregnancy but no additional increase with the onset of lactation. As the post-lactation period advanced, a dramatic decrease in VEGF was observed in the regressed mammary epithelium. The expression of VEGF suggests that mammary epithelium-derived VEGF may be involved in pregnancy-associated mammary growth and differentiation and angiogenesis, and regulate vascular permeability during lactation in an autocrine or paracrine manner.

Change in VEGF Expression in Mouse Mammary Gland during Reproductive Cycle