Open AccessInteraction of alkylmercuric compounds with sodium selenite. II. Metabolism of methylmercuric chloride administered alone and in combination with sodium selenite in rats.
Author(s) -
E A Brzeźnicka,
Jadwiga Chmielnicka
Publication year - 1985
Publication title -
environmental health perspectives
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.257
H-Index - 282
eISSN - 1552-9924
pISSN - 0091-6765
DOI - 10.1289/ehp.60-1568548
Subject(s) - selenium , chemistry , mercury (programming language) , sodium , metabolism , chloride , medicine , endocrinology , pharmacology , radiochemistry , biochemistry , biology , computer science , organic chemistry , programming language
Repeated doses of sodium selenite (Se) were administered to rats receiving repeated (IV or PO) doses of 0.25 or 2.5 mg Hg/kg methylmercuric chloride (Me2(203)Hg). Se (0.5 mg/kg) was observed to alter the distribution of Me203Hg among tissues as well as among subcellular fractions of kidneys and liver. An excess of selenium resulted in a twofold decrease in the mercury content of kidneys and a similar increase in the mercury content of brain.
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