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Toxicology, literally the scientific study of poisons, is a descriptiveand experimental science that details the biological consequences ofexposures to toxicants. The dose makes the poison—so goes the oft-repeated observation of the 16th-century progenitor of modernpharmacology, Theophrastus Paracelsus. Over the past three decades a growing number of

It's time to rethink dose: the case for combining cancer and birth and developmental defects.