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Schistosomiasis is the second commonest parasitic disease worldwide. It is responsible for thousandsof deaths per year in addition to the associating serious morbidities that burden both individuals andcommunities. To date, the main preventive measure of infection is mass treatment with praziquantel. itcarries the risk of reinfection and rising resistance which makes the discovery of an effective vaccinean urgent necessity. The present study evaluated E. camaldulensis killed cercariae immunogen (KCI)as a candidate vaccine for experimental schistosomiasis mansoni and to detect the possible immunologicalmechanisms of action of this immunogen. The KCI caused a significant reduction of bothschistosomula and adult worm counts with subsequent ova count reduction. Hepatic granulomas werereduced in number or size. Also, levels of IgG, IgG1 & IgG2a as well as INF-γ & IL-10 fluctuatedlarger than in natural infection.

EVALUATION OF THE EUCALYPTUS CAMALDULENSIS-KILLED CERCARIAE AS A CANDIDATE VACCINE FOR EXPERIMENTAL SCHISTOSOMIASIS MANSONI