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Background: poor responder management in IVF represents a critical dispute for fertility specialists. Meanwhile, there is a lack of evidence to support the use of any particular intervention to improve treatment outcomes in poor responders because of the small sample size and the heterogeneity between the trials on the definition of poor ovarian responders (POR). Objective: the aim of this study was to evaluate the role of transdermal testosterone on the probability of pregnancy achievement in poor responders undergoing ICSI trials. Thus, the number of oocytes, pregnancy rates (clinical and live birth) and HMG dose and duration were compared between both trials. Patients and Methods: This single-centre, randomized controlled trial was conducted from August 2016 to August 2017. A total of 61 poor responder patients with previous failed trial underwent their second ICSI trial. The patients received ovarian stimulation using a short GnRH agonist protocol in both trials with transdermal testosterone patches being used in the second trial starting five days prior to HMG. Results: The oocytes recruitment and the pregnancy rates were higher after testosterone pretreatment in the second trial, however, the difference between the previous and the second trial didn’t reach the statistical significance. Conclusion: Testosterone patches effect on oocyte number and pregnancy rates appears to be minimal for poor responders. However, further trials are needed to prove the study’s conclusion in the future.

The Role of Transdermal Testosterone Patch Over Pregnancy Rates in Poor Ovarian Responders Undergoing ICSI Cycles