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Background: Diabetes is a chronic metabolic disease which affects large number of population all over the world. Such disease is associated with many complications which may leads finally to patient’s mortality. More than 400 traditional medicinal plants have been recorded for helping in controlling such disease. So this study was planned to evaluate the effect of one of the famous plant mixture used in Saudi Arabia and some other Arab countries as hypoglycemic agent. Material and methods: Fourty adult male Albino Rats were divided into 8 experimental groups: The first group was considered as a control group.  The rest of groups were affected by induction of experimental diabetes by subcutaneous injection of Alloxan. The second group was consisted of diabetic rats without any treatment.The third group was treated by water mixture of the plants used. The fourth group treated with Nigella sativa while the fifth group treated with Aloe vera. The sixth one treated with Feruls assa foetida. The seventh group was treated with Boswellia carterii Birdw and finally the last group was treated with Commiphora myrrha.  The used plant dose was 1ml / 100gm body weight. After four weeks of treatment different physiological parameters were performed including estimation of the body weight, blood sugar level and serum insulin level. Pancreatic samples were obtained and processed for microscopic and quantitative evaluation after staining the prepared sections with both Heamatoxylin and eosin as well as special stain for demonstration of the different pancreatic cells in the Islet of the Langerhans. Results: The obtained results showed that the induced diabetes was diagnosed by laboratory assessment. The usage of the mixture or each plant alone was correct the glucose level,body weight gain and the insulin level.  Microscopically there was definite decrease in the number and diameter of beta pancreatic cells in the diabetic group while the other pancreatic cells were not affected (alpha and delta cells).  The use of medicinal plants in the different groups of this study greatly improves such cellular changes and the level of blood sugar level was corrected. The results obtained by the use of Commiphora myrrha was the best when compared with the rest of other plants. Delta cells were reduced in number and diameter with such treatment.    Conclusions: It is recommended from such study that the use of the plant mixture as a hypoglycemic agent may be of good results than the use of each plant separately besides repeating such study with the use of variable doses may be helpful in better evaluation for the required doses.

STRUCTURAL CHANGES IN THE PANCREAS OF EXPERIMENTAL DIABETIC RATS UNDER THE EFFECT OF SOME HYPOGLYCEMIC MEDICINAL PLANTS