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Experimental diabetes mellitus in rats was produced by a single dose of 200 mg of alloxan /kg body weight given intraperitoneally as an aqueous solution. The diabetic rats showed abnormal high blood glucose and variable increments in serum total lipids as well as in other serum lipid constituents particularly the triglycerides. Certain pathological abnormalities could be detected in both liver and kidney, particularly when the disturbances in glucose and lipid metabolism were more pronounced in a group of diabetic rats that received no insulin treatment {NIT} or after four weeks of the onset of diabetes. On the other hand, putting the group of diabetic rats on an insulin regimen from the start of the diabetic condition resulted in a significant restoration of most evaluated parameters to values almost similar to those of normal control animals. Diabetic rats receiving no insulin treatment showed a markedly significant loss in body weight; and started to gain body weight gradually when put on the proper insulin regimen.

Lipids and oxidative stress in blood serum of alloxan-induced diabetic rats: possible effects on liver and kidney tissues.