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To evaluate a possible relationship of maternal exposure to capsulation during postimplantation embryotoxicity, SWR pregnant female mice were injected intraperitoneally on day 4 of gestation with 7mg/kg cisplatin or with saline (0.4 ml) for the control group. Embryos were collected after 24h 48h, 72h, after injection. ultrastructural sections were used to investigate the mitochondria and the nuclear changes Both the mitochondria and the nuclei were damaged specially 48h and 72 h after injection they may be related to cytotoxicity of the drug.

Mitochondria and Nuclear changes in postimplanted mice embryos After treatment with Cisplatim antitumour drugs