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Objective: The present study aimed to investigate the pattern of expression of transforming growth factor & (TGF-&) and epidermal growth factor receptor (EGFR) in oral squamous cell carcinoma (OSCC) and to correlate their expression with tumor grading. Methods: ' ( ' ) *! +#,, )) ) Results:For both markers, positive staining reaction was characterized by cytoplasmic or cytoplasmic and membranous staining. EGFR was expre ' ./& ' 0 1! 2 ) ) ' particularly strong at the margin of invading cords and nests of tumour cells and poorly differentiated malignant cells. The expression of both markers was significantly correlated with histological grading; while the staining intensity showed no correlation with tumor grading. Conclusion: This study showed that OSCC express both EGFR and TGF-& and their expression indicated that these markers may have a potential diagnostic value in histologic examination. In addition their increased expression in high tumour grades suggest that they may be used as indicators of tumor aggressiveness.

Evaluation Of Transforming Growth Factor (Tgf- ) And Epidermal Growth Factor Receptor (Egfr) Expression In Oral Squamous Cell Carcinoma