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Background: Pregnancy misfortune happens in 0.5-1% of ladies. The etiology is frequently vague and might be multifactorial, with much debate in regards to determination and treatment. Objective: Investigating the relationship between serum progesterone and CA-125 distinguishing successful from unsuccessful pregnancy outcome during the first trimestic cases of threatened abortion. Patients and Methods: This clinical trial included 80 cases of confirmed intrauterine pregnancies between 6-12 weeks with demonstrable embryonic pulsation 40 asymptomatic patients and 40 cases complicated with vaginal bleeding. All cases were selected from Obstetrics and Gynecology Department, Al-Hussein and Sayed Galal Hospitals, Al-Azhar University, from December, 2018 to August, 2019. All patients showed an evidence of embryonic cardiac activity. CA-125 serum levels ware measured and compared with progesterone levels. Results: The mean level of CA.125 was 42.3±19.1 in threatened group and was 30.1±21.6 in normal group respectively. There was a statistically difference between the two groups regarding serum CA125. On the other hand, there was no statistically difference between the two groups regarding progesterone. ROC curve analysis showed 80.55% sensitivity and 100% specificity of CA125, and 78.65% sensitivity and 98.04% specificity of progesterone for prediction of the occurrence of miscarriage. Conclusion: Serum CA-125 seemed to be a promising biomarker for the early prediction of miscarriage

PREDICTIVE VALUE OF SERUM CA-125 VERSUS SERUM PROGESTERONE IN PREDICTING RISK OF PREGNANCY LOSS IN CASES OF FIRST TRIMESTERIC THREATENED ABORTION