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Objective: To investigate the clinical application value of four-dimensional color Doppler ultrasound in prenatal screening of fetal malformation. Methods: The comparative analysis was performed for 5033 pregnant women with 21-28 gestational weeks receiving two-dimensional ultrasound diagnosis and real-time four-dimensional color Doppler ultrasound in Nanning Eighth People's Hospital (hereinafter referred to as our hospital). Combined with the related data of pregnant women and four-dimensional color Doppler ultrasound results, the fetal malformation was judged. The review of the superior hospital, induced abortion results and imaging results of pregnant women after term delivery were used as the golden standard, and the relevant data were compared with the maternal abdominal examination. At the same time, the clinical specificity, sensitivity, negative detection rate and positive detection rate of the two diagnostic methods in the diagnosis of fetal malformation were compared. Results: The specificity, sensitivity, negative detection rate and positive detection rate of four-dimensional ultrasonic technique in the prenatal examination of fetal malformation were superior to those of two-dimensional ultrasound: There were (87+4897) cases consistent with the golden standard, 46 cases of missed diagnosis and 3 cases of misdiagnosis in two-dimensional ultrasound; there were (122+4900) cases consistent with the golden standard, 11 cases of missed diagnosis and no misdiagnosis in real-time four-dimensional ultrasound. And the differences between the two methods were statistically significant (P<0.05), and the real-time dynamic images could be obtained. Conclusion: Four-dimensional ultrasound applied in the prenatal analysis of fetal malformations can comprehensively observe the intrauterine fetal situation and improve the detection rate of fetal malformations, which can display the screening of fetal malformations most stereoscopically and intuitively and make up for the defects of two-dimensional ultrasound, so it is worthy of clinical application.

Analysis of Application of Four-dimensional Color Doppler Ultrasound in Prenatal Screening of Fetal Malformation