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Objective: Study the effects of Huangqi Dihuang pill(HDP) on immune function of immunosuppression mice. Methods: The mouse immunosuppression model was established by intraperitoneal injection of cyclophosphamide. intraperitoneal injection of chicken erythrocytes, intramuscular injection PHA, Then intraperitoneal injection of chicken erythrocytes and hennessy to detect the effects of Huangqi Dihuang pill on hemolysin, hemolytic plaque, lymphocyte transformation and phagocytosis of macrophages. Results: Huangqi Dihuang pill could improve the function of hemolysin, hemolytic plaque, lymphocyte transformation and macrophage phagocytosis of immunosuppression mice significantly (P<0.01). Conclusion: Huangqi Dihuang pill could improve the immune function of immunosuppression mice and is a potential immunomodulator. Introduction Immune system is an important system that body performs immune response and immune function. It has the function of identifying and eliminating the antigenic foreign body, coordinating with other systems of the body, and jointly maintaining the stability and physiological balance of the body. The imbalance and dysfunction of the immune system can lead to a range of related diseases, such as chronic inflammatory bowel disease (IBD)[1], autism (ASD)[2]. The immune system is classified into non-specific immunity and specific immunity, and specific immunity is divided into humoral immunity and cellular immunity. Subsequently, some scholars proposed the mucosal immune system and studied it as a relatively independent immune system[3]. Recent studies have shown that plant polysaccharides [4], flavonoids [5], glycosides [6] and other components have extensive immunological functions. Both astragalus and rhubarb are also recorded in the shennong grass sutra, which is also recorded in other medical literatures, and both contain polysaccharides, flavonoids, glycosides and other components. The preliminary study of the experimental team also showed that both the rhubarb and astragalus had enhanced immunity[7-8]. Huangqi dihuang pills are mainly composed of astragalus and rhubarb. Therefore, in this experiment, we discussed whether huangqi dihuang pills had an effect on immune function of the immunocompromised mice induced by humoral immunity from three aspects of humoral immunity (hemolysin, hemolytic plaque), cellular immunity (lymphocyte conversion rate) and non-specific immunity (macrophage phagocytosis).

The Effects of Huangqi Dihuang Pill on Immune Function of Immunosuppression Mice