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This study aimed to evaluate the association between gene vascular endothelial growth factor (VEGF)-634C/G polymorphism and diabetic retinopathy. Methods: Case–control and cohort studies about the association between gene VEGF polymorphism and diabetic retinopathy (DR) were searched on the Internet from the English and Chinese databases. Heterogeneity analysis was performed on the included studies using the Q test. RevMan5.3 was used to perform the meta-analysis. The outcomes across included studies were performed using fixed-effects and/or random-effects models.. Publication bias was assessed using a funnel plot. Results: A total of 14 studies were screened, and 2418 cases were found to have DR and 1798 case–controls had diabetes without retinopathy. The total odds ratio (OR) of gene VEGF-634C/G risk allele (C vs G) was 1.09 [95% confidence interval (CI) (0.90–1.31)], P = 0.40, P(heterogeneity)<0.00001; the total OR of genotype CC vs CG + GG was 1.28 [95% CI (0.97–1.68)], P = 0.08, P(heterogeneity) = 0.01; the total OR of CG vs CC + GG was 1.04 [95% CI (0.92–1.18)], P = 0.55, P(heterogeneity) = 0.22. Conclusion: No statistical significance existed between gene VEGT 634C/G and diabetic retinopathy.

Association Between the VEGF Gene Polymorphism and Diabetic Retinopathy Risk: A Meta-Analysis of 4216 Individuals