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Dear Editor, Creutzfeldt-Jakob disease (CJD) is a typically fatal neurodegenerative disease, and 90% of CJD patients die within 1 year of diagnosis. Of all CJD cases, 10–15% are autosomal dominant disorders of the prion protein gene (PRNP) in chromosome 20, classified as genetic or familial CJD. Familial CJD has an younger onset and has a lengthier disease progression than sporadic CJD.1 In the past, clinical patterns of CJD with M232R mutation (CJD232) were like sporadic CJD. However, CJD232 cases that reveal longer clinical courses and periodic sharp and wave complexes distinctively found in an eletroencephalography (EEG) are not observed have been recently reported.2 The authors report cases of patients diagnosed with familial CJD revealed slow progress like Alzheimer’s disease. A 62-year-old male patient visited our hospital because he had gait disturbance 2 years ago and symptoms of memory deterioration, etc. occurred 1 year ago. In his medical history, Familial Creutzfeldt-Jakob Disease with M232R Mutation Progressed Slowly like Alzheimer’s Disease

Familial Creutzfeldt-Jakob Disease with M232R Mutation Progressed Slowly like Alzheimer's Disease