Open AccessAmiodarone-Induced Pulmonary Toxicity: Percutaneous Needle Aspiration Biopsy and Ultrastructural Findings
Author(s) -
In Sook Kang,
Jin Hwa Lee,
Sun Hee Sung,
SeongHoon Park
Publication year - 2013
Publication title -
the ewha medical journal
Language(s) - Uncategorized
Resource type - Journals
eISSN - 2234-2591
pISSN - 2234-3180
DOI - 10.12771/emj.2013.36.2.144
Subject(s) - amiodarone , pulmonary toxicity , medicine , toxicity , cardiology , pharmacology , atrial fibrillation
Amiodaronehasbeenwidelyusedforsupraventricularandventriculararrhythmias andmanypatientsbenefitfromitseffectivenessintreatingpotentiallylife-threatening arrhythmias.However,thisdrugcancausemulti-organtoxicity,includingamiodarone- inducedpulmonarytoxicity(APT).Notonlydoesamiodaronehavealonghalf-life butalsoislipophilicandthereforecaneasilyaccumulateintissues.Hence,itisdifficult tomonitortherapeuticlevelsandsideeffects,makingitdifficulttopredicttoxicities. Inthiscase,wedescribemulti-organcomplicationssecondarytoamiodaroneuse, especiallyAPTcombinedwithpneumoniawithatypicalpathogensandpulmonary hemorrhage.Thepatientreachedahighcumulativedoseofamiodaronedespitealow maintenancedoseofamiodarone.ThiscasehighlightsanunusualpresentationofAPT withmulti-organtoxicityandwereviewarticlesregardingtheassociationbetweenthe cumulativedoseofamiodaroneandamiodarone-inducedtoxicities. (Ewha Med J
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