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Ferrite-Adriamycin-microcapsule (Ferrite-ADR-m.c.), a new chemo-embolic material, was developed to improve the therapeutic effect with magnetic field for transcatheter arterial chemo-embolization (TACE) of malignant tumors. Ferrite-ADR-m.c. was prepared by the spray drying method. The physical character of Ferrite-ADR-m.c. was investigated and the embolization effect of Ferrite-ADR-m.c. under the magnetic field was studied in rabbit ear vein. Fifteen adult rabbits (male, 2.8•`3.3kg) with VX2 tumor in the right thigh, which grew up to 3.0 cm in diameter, were separated into the following three groups: (1) 7 rabbits of TACE with Ferrite-ADR-m.c., (2) 3 of ADR arterial infusion and (3) 5 of no treatment as a control group. In TACE group, a 3.0 French catheter was selectively introduced into the feeding artery of the VX2 tumor and 41.7 mg/kg (ADR: 0.5 mg/kg) FerriteADR-m.c. was infused through the catheter under 5 mT magnet. Only 0.5 mg/kg ADR was infused in the arterial infusion group. Before and after TACE, digital subtraction angiography (DSA) and computed tomography (CT) were performed. After sacrifice at seven days or natural death, histological examinations with light and scanning electron microscope (SEM) were performed. Ferrite-ADR-m.c. consisted of 8.47 •~ 10-1 g/g Ferrite as the core, which is 1.2 •~ 10-2 g/g active ADR and 1.41 •~ 10-1 g/g ethylcellulose as the shell. It was recognized with SEM that Ferrite-ADR-m.c. presented a spherical shape measuring 9.9 •} 2.4 ƒÊm (mean •} S.D.) in diameter, having a relatively smooth surface. The mass magnetization was 53.0 emu/g when 1 mT magnetic field was given. The release rate of ADR from Ferrite-ADR-m.c. was rated as very slow. According to the theoretical consideration, it was confirmed that Ferrite-ADR-m.c. could be fixed in arterioler lumen when the relation between the intensity of the magnetic field (H) and the velocity of the blood flow (v) was satisfied with the formula H•†7.48 •~ 103 •~ v. Soft X-ray radiograms of the rabbit ear confirmed that Ferrite-ADR-m.c. was fixed in the ear vein and complete occlusion was made under 6 mT magnet. DSA images after TACE demonstrated that the feeding arteries of VX2 tumor were completely embolized by Ferrite-ADR-m.c. The high density area, in which CT number from 300 to 400 H.U. indicating the existence of Ferrite-ADR-m.c., was recognized as the tumor after TACE. The microembolus was observed in many arterioles of VX2 tumor, surrounded by degenerative and necrotic tumor cells in histologic specimens. It was confirmed by Fe stain and EDAX (Energy dispersive analysis X-ray) that the microembolus was made up mainly of iron identifiable as Ferrite-ADR-m.c. The reduction rate of the tumor and the inhibition effect of metastasis in TACE group were more excellent than those of the other two

Fundamental studies of transcatheter arterial chemo-embolization with adriamycin microcapsules containing ferromagnetic microparticles as the core.