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To evaluate altered GH regulation in MSG rats, plasma GH profiles were observed in unrestrained adult male MSG rats that had received a continuous infusion of human GRF [1-44] NH2. Male Wistar rats were treated with MSG (4 mg/g BW, sc) as neonates and were used for the study on 150•`170 days of life. All rats were provided with two indwelling cannulae 5•`7 days previously; one in the right atrium for undisturbed blood collection and the other in the inferior vena cava for 0.9% NaCI or GRF infusion. 0.9% NaCI or GRF was administered by an infusion pump (10 ƒÊl/min) for 6 h at a dose of 50 or 200 ng/kg BW/min. Serial blood samples were obtained every 20 min. During a 6-h continuous infusion of 0.9% NaCI, plasma GH levels in MSG rats were low and revealed occasional small elevations, while in the control animals characteristic pulsatile GH secretion was observed every 173 min. During a low dose GRF (50 ng/kg BW/min) infusion in MSG rats, pulsatile GH secretion appeared at irregular intervals, while in control rats the amplitude of naturally occurring pulsatile GH secretion was significantly augmented. In MSG rats, plasma GH levels rose without pulsatile manner during a high dose GRF (200 ng/kg BW/min) infusion. When the control rats received a high dose GRF infusion, the amplitudes of pulsatile GH secretion and trough GH levels were markedly augmented but the interval of pulsatile GH secretion remained unaltered. The amount of GH released during a 6-h continuous GRF infusion -increased significantly in a dose dependent manner in both groups of rats , but it was significantly less in MSG rats than in control rats. When the rats had received goat anti-somatostatin serum previously, plasma GH levels during GRF infusion rose without pulsatile secretion. Results show that in adult male MSG rats, pulsatile GH secretion can be resumed by a continuous infusion of GRF, but the release of somatostatin which exerts the intermittent tonic inhibition on GH secretion during a continuous presence of GRF is compromised.

Growth hormone(GH) secretion during a 6-hour continuous infusion of GH-releasing factor(GRF) in monosodium glutamate(MSG) administered rats.