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Numerous literatures have been documented concerning CEA as a tumor marker and immunoparameters in the cancer patients. These reports may be theoretically acceptable, but it seems questionable whether they are clinically applicable or not. In this context, we have studied various items considered as immunoparameters in the urogenital cancer patients and obtained some findings as described below. The peripheral blood from the patients suffering from the urogenital carcinoma was taken and subjected for various immunoparameters determination after confirming the definite clinical diagnosis after hospitalization. Moreover, the urogenital cancer patients were classified into T classification by organs (bladder, prostate and kidney). They were classified into metastatic and non-metastatic groups for the further investigation. Yata, et al. had reported that Con A induced suppressor T cells better than PHA, we have investigated from the standpoint that Con A/PHA reactivity ratio was consistent well with clinical pictures. The predominance of PHA over Con A became reversed with advanced cancer. Such reversion seemed to play an important role clinically in the prediction of prognosis and observation of the course of therapy in cancer patients. When T cell subpopulation was examined by the statistical analysis of our data, measurements of T and B cells showed large dispersion probably depending on infection and other factors in cancer patients and no significant difference was noted. Moreover, no theoretically acceptable values were obtained for individual data. However, IgGFcR+ T cells showed a tendency to increase with advanced cancer, reflecting suppressor T cells. Accordingly, both T and B cells were considered to be inadequate for clinical use as immunoparameters and therefore, these were not discussed hereafter. One hundred thirty three cases including the control are subjected for the further

A comparative evaluation on nonspecific immunoparameters and CEA as a tumor marker in urogenital cancer patients.