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(1) Effects of single shock stimulation of the mid-brain reticular formation, the amygdala, the sciatic nerve, and the structures near the tympanic cavity upon hippocampal pyramidal cells were studied by means of intracellular microelectrodes in rabbits, anesthetized with Nembutal and immobilized with D-tubocurarine. (2) Regardless of site of stimulation, the responses induced were categorized into the following two types. Namely, they were either simple spike discharges with underlying small depolarizations or inactivation responses (IRs), i.e., large prolonged depolarizations with superposed spike bursts exhibiting progressive spike inactivations (magnitude: more than 20mV, duration: more than 40 msec). (3) The IR was always produced in all-or-nothing fashion despite changes in the site of stimulation. Evidence was also found that the individual IR could be further subdivided into several components having an all-or-nothing property. (4) Responses resulting from stimulation of the structures mentioned above exhibited long and variable latencies. These results indicate that the effect of stimulating these structures reached the hippocampus via multi-synaptic pathways. (5) Stimulation of the mid-brain reticular formation could induce a potential resembling in waveform a pseudo-DAP (depolarizing after-potential) without being preceded by a spike. This is compatible with an earlier report that the pseudo-DAP in hippocampal pyramidal cells is independent of the spike. (6) It was revealed that injury discharge of pyramidal cells could consist of rhythmically recurring IRs. As the cell deterioration progressed, the fast spikes, presumably somatic in origin, soon became totally inactivated, but the slow component of the IR survived without any appreciable changes in waveform. This is in agreement with the notion that the IR originates in the dendrites.

Mode of transsynaptic activation of hippocampal pyramidal cells in rabbits