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et al. found that Nocardia strain IFM 0273 isolated from the cutaneous nocardiosis of an 82-year-old male patient in Fukuoka, Japan, produced a substance toxic to cultured cells.2>3) That toxic substance was called HS-6 toxin, and the structure of HS-6 toxin was found to belong to the 1 6-membered macrocyclic group with a molecular formula of C43H68O12.3) Nocardial infections in the immunocompromised host are well known.4) Since the Nocardia strain was found to produce a toxic substance, it would be of considerable interest to find what influences the HS-6 toxin have on animals. In this paper, HS-6 was administered to mice and tissues were then observed morphologically.

Fatty degeneration of the liver induced by HS-6 toxin produced by Nocardia otitidiscaviarum from human cutaneous nocardiosis.