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Cimetidine, which is marketed under the trade name Tagamet, is one of the most potent histamine H2 receptor antagonists for inhibiting excessive acid secretion caused by histamine, and is currently in worldwide clinical use for treating peptic ulcers.i"2) Recently, we have found that this drug exhibited dramatic reactivity with oxygen-derived free radical species. Hence, we focused on its specific

Cimetidine anti-ulcer drug as a powerful hydroxyl radical scavenger.