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It has been required that strains of yeast and bacteria to be used for the production of single cell protein should be carefully checked as to their potential pathogenicity beforehand. A procedure for assessing the potential pathogenicity of yeasts was proposed after 9 years research work,1'2* which was briefly introduced in this journal.3) Thereafter, an attempt was madeto apply the proposed procedure to the assessment of the potential pathogenicity of bateria.1} The applied procedure in brief is as follows: One-tenth ml per head of a suspension containing 108 colony forming units of washed vegetative cells is inoculated into the tail veins of 10 specific pathogen-free female mice of about 5 weeks of age. The mice are sacrificed after 14 days, and the liver, kidneys, and brain are collected. The surface of an agar culture plate is rubbed with a section of each of the organs, and then the plates are incubated, after which the colonies on the surface are counted. Specimens of the organs are prepared for histopathological examination. The counts of colonies on the plates are given scores from 0 to 4; A score of0 forno colonies, 1 for less than 10 colonies, 2 for less than 50, 3 for less than 100, and 4 for over 1 00. The results of histopathological examination are also given scores from 0, for no apparent change, to 4, for the severest change in the organs. The sumof the scores for the 3 organs gives the total score for an individual mouse. A total score of 12 is given for a mousethat dies within 14 days, and one of 15 for a mouse that dies within the first 5 days. The discrimination function, Z, is calculated using Eq. (1),

Assessment of the pathogenicity of bacteria used in the production of single cell protein.