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Eighteen male guinea pigs were divided into two groups and fed for 2 weeks with a diet containing 284 ppm of vitamin C and 50 ppm of vitamin E. One group received autoxidized linseed oil (40 mg/animal/day) three times during the feeding. Compared with the animals not given the oxidized oil, the body weight gains, liver ascorbic acid levels and α-tocopherol contents were significantly decreased and liver lipid peroxidation was greatly stimulated in the animals dosed with the oxidized oil. In the next experiment, forty male guinea pigs were divided into five groups; only one group received a diet containing 1000 ppm of vitamin C and 50 ppm of vitamin E without oxidized oil, and the other four groups received graded diets of 1000~3000 ppm of vitamin C and 50~200 ppm of vitamin E for 35 days. To the latter four groups, the oxidized oil (24 mg/animal/day) was orally administered 12 times during the feeding period. The tocopherol contents of the kidney and lung were found to be lower in the animals fed with a 3...

Effect of dietary vitamin C and vitamin E on tissue lipid peroxidation of guinea pigs fed with oxidized oil.