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Problems involved in the preliminary selection of colonies with regard to production of some metabolites directly at the stage of petri plates, have been solved up to now in a rather restricted number of instances: Available methods include mainly screening of antibiotic production,1~3) tests for the detection of enzymatic activity. or demonstration of acidity or alkalinity development.8'9* Should not the compound of interest fall within these and few other classes, routine procedure involves a number of steps from colony isolation to shaking culture that are time-consuming and require substantial personnel and laboratory facilities' availability. In order to improve the potential of our screening programs in search of blocked or impaired mutants of macrolide antibiotics' producers, we have developed a new approach that allows the preliminary selection of a very large number of colonies in a short period. In this technique, distinct, well separated colonies resulting from a mutagenic treatment are individually cut-down and picked-up together with the underlying agar disk by a short cork borer adapted to a syringe (alternatively the same operation maybe performed on colonies grownon separate small pieces of agar mediumaccording to the Ishikura technique10*).

agricultural and biological chemistry

New screeing method for the rapid identification of blocked mutants and their products. Application to erythromycin and oleandomycin producing strains.