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The resistance of a bacterium to lethal and/or mutagenic action of various agents which damage to DNA depends on its repair capability for this damage. Since the repair capability varies with different phys iological conditions, it would be expected that lethal and mutagenic effects in the repair-proficient bacteria can be modified by physiological changes during the recovery process. Cells of M. radiodurans irradiated with sublethal doses of ƒÁ-rays lose their colony-forming ability by the postincubation for several hours under nonpermissive conditions for growth.1•`3) Interruption of DNA strand rejoining by the addition of some antibiotics to a postincubation medium reduces cell survivors.1,2) The cells irradiated with sub-lethal doses are killed by

Enhanced lethal effect of various agents on M. radiodurans by postincubation at nonpermissive temperature.